Abbracchio M P, Burnstock G
Institute of Pharmacological Sciences, University of Milan, Italy.
Jpn J Pharmacol. 1998 Oct;78(2):113-45. doi: 10.1254/jjp.78.113.
In this review, after a summary of the history and current status of the receptors involved in purinergic signalling, we focus on the distribution and physiological roles of purines and pyrimidines in both short-term events such as neurotransmission, exocrine and endocrine secretion and regulation of immune cell function, and long-term events such as cell growth, differentiation and proliferation in development and regeneration. Finally, the protective roles of nucleosides and nucleotides in events such as cancer, ischemia, wound healing, drug toxicity, inflammation and pain are explored and some suggestions made for future developments in this rapidly expanding field, with particular emphasis on the involvement of selective agonists and antagonists for purinergic receptor subtypes in therapeutic strategies.
在本综述中，在总结嘌呤能信号传导相关受体的历史和现状之后，我们重点关注嘌呤和嘧啶在短期事件（如神经传递、外分泌和内分泌分泌以及免疫细胞功能调节）和长期事件（如发育和再生中的细胞生长、分化和增殖）中的分布及生理作用。最后，探讨了核苷和核苷酸在癌症、缺血、伤口愈合、药物毒性、炎症和疼痛等事件中的保护作用，并对这一迅速发展的领域的未来发展提出了一些建议，特别强调了嘌呤能受体亚型的选择性激动剂和拮抗剂在治疗策略中的作用。
