Fraunholz I B, Schopohl B, Böttcher H D
Klinik für Strahlentherapie und Onkologie, Klinikum der Johann-Wolfgang-Goethe-Universität Frankfurt/Main.
Strahlenther Onkol. 1998 Nov;174 Suppl 3:90-2.
Acute and late injuries of vulva and vagina are frequent and potentially serious complications in radiotherapy of gynecologic tumors. They still are reported poorly in literature.
Based on a literature search a survey will be given of the modalities, which are used or recommended for prophylaxis or treatment of these radiation injuries. The principles of the different measures will be discussed with available study results.
Hygiene measures and the topical application of antimicrobial or granulation stimulating substances, which is mostly based on long standing clinical experience, are the principles of the treatment of acute reactions of vulva and vagina. The topical use of estrogen, which promotes proliferation of epithelium, is generally described in connection with treatment and prophylaxis of late radiation injuries. As a prophylaxis for the late reaction of vaginal stenosis, vaginal dilatation is recommended in literature.
With the exception of a few reports on estrogen, there are no data about the effectiveness of the currently used medical substances. The local application of estrogen as prophylaxis of the acute reactions will therefore be examined in a prospective study.
外阴和阴道的急性及晚期损伤是妇科肿瘤放疗中常见且可能严重的并发症。然而，相关文献报道仍较少。
通过文献检索，将对用于预防或治疗这些放射性损伤的方法进行综述。将结合现有研究结果讨论不同措施的原则。
卫生措施以及局部应用抗菌或促进肉芽生长的物质，这大多基于长期临床经验，是外阴和阴道急性反应的治疗原则。局部使用雌激素可促进上皮细胞增殖，通常在晚期放射性损伤的治疗和预防中提及。文献推荐阴道扩张作为预防阴道狭窄晚期反应的方法。
除了少数关于雌激素的报道外，目前尚无关于所用药物有效性的数据。因此，将通过前瞻性研究来检验局部应用雌激素预防急性反应的效果。
