Hobbs R E
Department of Cardiology, Cleveland Clinic, USA.
Cleve Clin J Med. 1998 Nov-Dec;65(10):539-42. doi: 10.3949/ccjm.65.10.539.
In a large, randomized study, patients with heart failure who received a large daily dose of an angiotensin-converting inhibitor had a trend toward a lower mortality rate than did patients who received a low daily dose. Moreover, the hospitalization rate was lower in the high-dose group, and the side-effect profile was the same in both groups. Physicians should try to give maximal doses to achieve optimum benefit in this patient population.
