Raychaudhuri S, Rock K L
Corixa Corporation, Seattle, WA 98104, USA.
Nat Biotechnol. 1998 Nov;16(11):1025-31. doi: 10.1038/3469.
Developments in methods for identifying antigens from infectious agents and cancers has provided exciting new opportunities in prevention and treatment through vaccination. In many of these situations, however, traditional immunization techniques do not stimulate protective immunity because they fail to fully mobilize the appropriate immune responses. This limitation, together with new insights into the underlying mechanism of immune responses, has spurred development of several new approaches for vaccine delivery. We discuss some of the current efforts being developed to provide effective vaccine delivery systems.
从传染病原体和癌症中识别抗原的方法进展，为通过疫苗接种进行预防和治疗提供了令人兴奋的新机会。然而，在许多此类情况下，传统免疫技术无法刺激保护性免疫，因为它们未能充分调动适当的免疫反应。这一局限性，加上对免疫反应潜在机制的新认识，推动了几种新型疫苗递送方法的发展。我们讨论了目前为提供有效的疫苗递送系统而开展的一些工作。
