Murray T K, Ridley R M
Astra Arcus AB, Södertälje, Sweden.
Behav Pharmacol. 1997 Oct;8(5):383-8.
The effect of the non-competitive N-methyl-D-aspartate (NMDA)-receptor antagonist, dizocilpine (MK-801) on the acquisition and reversal of conditional tasks was investigated using a Y-maze. Dizocilpine-treated rats were severely impaired on acquisition of a visuo-spatial task and were unable to learn the reversal of this task. 'Worse than chance' performance by dizocilpine-treated (and saline-treated) rats at the beginning of reversal testing, which was given 24 h after achieving criterion on acquisition, indicated that dizocilpine-treated animals simultaneously exhibited good memory but impaired learning for the type of information required for this task. Dizocilpine-treated rats were unable to acquire a visuo-visual conditional discrimination and therefore could not be assessed on reversal of this task. These very substantial impairments were larger than those found in comparable experiments using non-conditional tasks.
使用Y迷宫研究了非竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂地佐环平（MK-801）对条件性任务的习得和逆转的影响。接受地佐环平治疗的大鼠在视觉空间任务的习得方面严重受损，并且无法学会该任务的逆转。在习得达到标准后24小时进行的逆转测试开始时，接受地佐环平治疗（和生理盐水治疗）的大鼠表现“比随机水平还差”，这表明接受地佐环平治疗的动物同时表现出良好的记忆，但对于该任务所需信息类型的学习受损。接受地佐环平治疗的大鼠无法习得视觉-视觉条件性辨别，因此无法对该任务的逆转进行评估。这些非常严重的损伤比在使用非条件性任务的可比实验中发现的损伤更大。
