Santavirta S, Takagi M, Nordsletten L, Anttila A, Lappalainen R, Konttinen Y T
Department of Orthopaedics and Traumatology, Helsinki University Central Hospital, Finland.
Arch Orthop Trauma Surg. 1998;118(1-2):89-91. doi: 10.1007/s004020050319.
We studied the possible use of silicon carbide (SiC) as a ceramic coating material of titanium-based total hip replacement (THR) implants. The idea is to prevent wear debris formation from the soft titanium surface. SiC is a hard and tightly bonding ceramic surface material, and because of these physical properties it is not easily degradable, as is the case with hydroxyapatite. Our previous in vivo and in vitro studies have indicated that SiC and hydroxyapatite are equally biocompatible regarding particle size for phagocytosis. The present cytotoxicity test using JCRB0603 cells showed that 5 microns SiC particles inhibited colony outgrowth by one-third (67% + 10% vs control), while SiC-coated pins did not cause any inhibition and acted similarly to uncoated titanium pins. The results support the hypothesis that SiC is a promising ceramic THR implant coating material.
我们研究了碳化硅（SiC）作为钛基全髋关节置换（THR）植入物陶瓷涂层材料的潜在用途。其目的是防止软质钛表面形成磨损颗粒。SiC是一种坚硬且结合紧密的陶瓷表面材料，由于这些物理特性，它不像羟基磷灰石那样容易降解。我们之前的体内和体外研究表明，就吞噬作用的颗粒大小而言，SiC和羟基磷灰石具有同等的生物相容性。目前使用JCRB0603细胞进行的细胞毒性测试表明，5微米的SiC颗粒使集落生长受到三分之一的抑制（67% + 10%，与对照组相比），而涂有SiC的销钉未产生任何抑制作用，其作用与未涂层的钛销钉类似。这些结果支持了以下假设：SiC是一种有前景的陶瓷THR植入物涂层材料。
