Preobrazhenskiĭ Iu B, Prianishnikova N T, Charintsev V G
Zh Ushn Nos Gorl Bolezn. 1976 Jul-Aug(4):73-7.
The authors present data on a comparative study of the effect of pyromecaine, cocaine and pontocaine during a number of otorhinolaryngeal operations. A device was developed for objective evaluation of anesthesia, which graphically records the extent and duration of anesthesia in patients. Pyromecaine was used during 420 operations and manipulations in 397 patients with diseases of the nose and nasal accessory sinuses aged from 14 to 82 years. The control group consisted of 200 patients subjected to the same operations with the use of cocaine and pontocaine. Data on algography and observations of the general condition in patients showed that 2% pyromecaine solution caused good anesthetic effect in 91%, satisfactory anesthetic effect in 8%, and unsatisfactory anesthetic effect in 1% patients. On the grounds of the conducted clinical studies the authors concluded that pyromecaine approaches pontocaine in respect to the extent and duration of its effect and exceeds cocaine by 2-2.5 times. They recommend pyromecaine for certain otorhinolaryngeal operations.
作者介绍了对鼻咽喉手术中吡咯卡因、可卡因和丁卡因效果的比较研究数据。研发了一种用于客观评估麻醉效果的装置，该装置以图表形式记录患者麻醉的范围和持续时间。对397例年龄在14至82岁的鼻及鼻窦疾病患者进行了420次手术和操作，术中使用了吡咯卡因。对照组由200例使用可卡因和丁卡因进行相同手术的患者组成。痛觉记录法数据及对患者一般状况的观察表明，2%吡咯卡因溶液在91%的患者中产生了良好的麻醉效果，8%的患者麻醉效果满意，1%的患者麻醉效果不满意。基于所进行的临床研究，作者得出结论：吡咯卡因在作用范围和持续时间方面与丁卡因相近，且效果比可卡因强2至2.5倍。他们推荐在某些鼻咽喉手术中使用吡咯卡因。
