Günaydin I, Daikeler T, Jacki S, Mohren M, Kanz L, Kötter I
Department of Rheumatology and Hematology, Eberhard-Karls-University, Tübingen, Germany.
Rheumatol Int. 1998;18(3):93-6. doi: 10.1007/s002960050064.
Our objective was to study joint symptoms in patients with relapsing polychondritis (RP) and their relationship to other clinical manifestations and laboratory findings. Fourteen patients who met the diagnostic criteria proposed by Michet et al. for RP were studied. Clinical symptoms were recorded and a detailed laboratory analysis with HLA-DR typing was carried out. In 2 patients arthritis was the first manifestation. During the follow-up, 10 patients developed arthritis. It was polyarticular in 6, and oligoarticular in 4 cases. The development of arthritis was unrelated to the appearance of chondritis at other sites. HLA class II typing was determined in 7 patients. Six of them were positive for HLA-DR4. Arthritis in RP is a frequent manifestation occurring in approximately 70% of patients with an asymmetric articular involvement. There is no correlation between articular involvement and any particular clinical or laboratory feature. Susceptibility to RP is significantly related to the presence of HLA-DR4.
我们的目的是研究复发性多软骨炎（RP）患者的关节症状及其与其他临床表现和实验室检查结果的关系。对14例符合米歇特等人提出的RP诊断标准的患者进行了研究。记录临床症状，并进行了包括HLA - DR分型在内的详细实验室分析。2例患者关节炎为首发表现。随访期间，10例患者出现关节炎。其中6例为多关节型，4例为少关节型。关节炎的发生与其他部位软骨炎的出现无关。对7例患者进行了HLA II类分型。其中6例HLA - DR4呈阳性。RP中的关节炎是一种常见表现，约70%的患者会出现，关节受累不对称。关节受累与任何特定的临床或实验室特征之间均无相关性。RP易感性与HLA - DR4的存在显著相关。
