Harabin-Słowińska M, Słowiński J, Konecki J, Mrówka R
Department of Histology and Embryology, Silesian School of Medicine, Zabrze.
Folia Neuropathol. 1998;36(3):179-84.
Expression of CD44 (m.w. 80-95 kD) in 48 metastatic brain tumors was examined using monoclonal antibody on paraffin sections. The CD44 expression was found in 48% of studied tumors. The most constant expression of CD44 was observed in metastases from thyroid, skin and breast cancer. The brain metastases were characterized by quite heterogenous distribution of CD44 glycoprotein--the most pronounced expression was seen in individual neoplastic cells embedded in abundant stroma and in the vicinity of preserved neural tissue. Such a topographical distribution of CD44 supports its role in interactions of cancer cells with extracellular matrix components of the tumor stroma as well as of neural tissue.
使用单克隆抗体在石蜡切片上检测了48例转移性脑肿瘤中CD44（分子量80 - 95 kD）的表达。在48%的研究肿瘤中发现了CD44表达。CD44最稳定的表达见于甲状腺、皮肤和乳腺癌的转移瘤。脑转移瘤的特点是CD44糖蛋白分布相当不均一——在嵌入丰富基质中的单个肿瘤细胞以及保留的神经组织附近可见最明显的表达。CD44的这种拓扑分布支持其在癌细胞与肿瘤基质以及神经组织的细胞外基质成分相互作用中的作用。
