Smiałek M, Gajkowska B, Ostrowski R P, Piotrowski P
Department of Neuropathology, Polish Academy of Sciences, Warszawa.
Folia Neuropathol. 1997;35(4):262-4.
To investigate the influence of squalene on the nervous system, adult male Wistar rats were injected with squalene subcutaneously with 20 g/kg of the body weight for 4 consecutive days. After 7 or 30 days from the initiation of the experiment, brain and ischiadic nerves were harvested for electron microscopy. Squalene affected mostly PNS targeting Schwann cells and myelin sheaths. Accumulation of lipid-like droplets in the myelin sheaths in the PNS and in the neurons in the brain cortex, hypertrophy of endothelium, and sometimes endothelial apoptosis in blood vessels, and increased synthesis of collagen in the ischiadic nerve were characteristic for developed squalene encephaloneuropathy.
为研究角鲨烯对神经系统的影响，将成年雄性Wistar大鼠按20克/千克体重皮下注射角鲨烯，连续注射4天。实验开始7天或30天后，采集大脑和坐骨神经用于电子显微镜检查。角鲨烯主要影响周围神经系统中的施万细胞和髓鞘。周围神经系统的髓鞘以及大脑皮质神经元中出现类脂滴积聚、血管内皮肥大，有时还出现内皮细胞凋亡，坐骨神经中胶原蛋白合成增加，这些都是典型的角鲨烯性脑神经病表现。
