Albuquerque F C, Hinton D R, Weiss M H
Department of Neurological Surgery, University of Southern California School of Medicine, Los Angeles 90033, USA.
J Neurosurg. 1998 Dec;89(6):1043-6. doi: 10.3171/jns.1998.89.6.1043.
The authors report the case of a 48-year-old woman who presented with a nonprolactin-secreting adenoma and a preoperative prolactin level of 662 ng/ml. The patient's neoplasm subsequently enlarged despite normalization of her prolactin level with dopamine agonist therapy. Hyperprolactinemia, with levels of prolactin as high as 150 ng/ml, is commonly associated with sellar tumors and is attributed to disruption of the normal delivery of dopamine to the adenohypophysis. The prolactin level found in this patient represents the highest level attributed to the stalk-section effect reported in the literature and underscores the need for repeated radiographic assessment of patients who are undergoing treatment with bromocriptine and have prolactin levels in the 25 to 1000 ng/ml range.
作者报告了一例48岁女性病例，该患者患有非分泌泌乳素腺瘤，术前泌乳素水平为662 ng/ml。尽管通过多巴胺激动剂治疗使患者的泌乳素水平恢复正常，但肿瘤随后仍增大。泌乳素水平高达150 ng/ml的高泌乳素血症通常与鞍区肿瘤有关，这归因于多巴胺向腺垂体的正常输送受到破坏。该患者的泌乳素水平是文献报道的因垂体柄横断效应所致的最高水平，这突出表明对于正在接受溴隐亭治疗且泌乳素水平在25至1000 ng/ml范围内的患者，需要反复进行影像学评估。
