Gibbons G H
Department of Medicine, Harvard Medical School and Brigham & Women's Hospital, Boston, Massachusetts 02115, USA.
Am J Hypertens. 1998 Nov;11(11 Pt 2):177S-181S. doi: 10.1016/s0895-7061(98)00198-8.
Emerging data on the role of the tissue renin-angiotensin system are redefining our understanding of the pathophysiology of hypertension and other vascular disorders. Although the tissue renin-angiotensin system is quiescent after birth, it can be reactivated in response to tissue injury. Recent evidence suggests that this system is involved in maladaptive changes such as ventricular and vascular remodeling, alterations in renal function, and atherosclerosis. With increased recognition of the role of angiotensin II in these processes, new therapeutic opportunities are emerging. Blockade of angiotensin II will likely prove more effective than other vasodilator therapies in the setting of congestive heart failure and after acute myocardial infarction.
关于组织肾素 - 血管紧张素系统作用的新数据正在重新定义我们对高血压和其他血管疾病病理生理学的理解。尽管组织肾素 - 血管紧张素系统在出生后处于静止状态，但它可因组织损伤而重新激活。最近的证据表明，该系统参与了诸如心室和血管重塑、肾功能改变以及动脉粥样硬化等适应性不良变化。随着对血管紧张素 II 在这些过程中作用的认识不断增加，新的治疗机会正在出现。在充血性心力衰竭和急性心肌梗死后，阻断血管紧张素 II 可能比其他血管扩张剂疗法更有效。
