戊型肝炎病毒：一株尼泊尔分离株的全基因组序列及系统发育分析
Hepatitis E virus: complete genome sequence and phylogenetic analysis of a Nepali isolate.
作者信息
Gouvea V, Snellings N, Popek M J, Longer C F, Innis B L
机构信息
Department of Virus Diseases, Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA.
出版信息
Virus Res. 1998 Sep;57(1):21-6. doi: 10.1016/s0168-1702(98)00079-3.
The complete nucleotide sequence of the Nepali strain TK15/92 of hepatitis E (HEV) was determined. It showed the highest sequence homology with the Burmese B1 strain, but closer evolutionary relatedness to the Indian strains. Difficulties in reverse-transcribing and amplifying the hypervariable region in ORF1 suggested that strong secondary structures might be intrinsically responsible for the high mutational rate observed in this region of the HEV genome.
测定了戊型肝炎病毒（HEV）尼泊尔毒株TK15/92的完整核苷酸序列。它与缅甸B1毒株的序列同源性最高，但与印度毒株的进化关系更密切。在ORF1中逆转录和扩增高变区存在困难，这表明强大的二级结构可能是HEV基因组该区域观察到的高突变率的内在原因。
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