Moretti C, Sauvain M, Lavaud C, Massiot G, Bravo J, Muñoz V
Institut Français de Recherche Scientifique pour le Développement en Coopération (ORSTOM), Unité de Recherche No. 45, 209-213 rue La Fayette 75480 Paris Cedex 10, France.
J Nat Prod. 1998 Nov;61(11):1390-3. doi: 10.1021/np9800654.
A new aminosteroid, 3beta-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-beta-D-glucopyranosyl-eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 microM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 microM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.
从刺毛萨拉查（Saracha punctata）的叶子中分离出一种新的氨基甾体化合物，名为3β-氨基-22,26-表亚氨基胆甾-5-烯（sarachine，1），以及两种已知的黄酮类化合物，圣草酚（eriodictyol，2）和7-O-β-D-吡喃葡萄糖基圣草酚（7-O-beta-D-glucopyranosyl-eriodictyol，3）。发现该生物碱可抑制巴西利什曼原虫前鞭毛体的生长（在25 μM时抑制率为100%）以及培养的克氏锥虫上鞭毛体的生长（在25 μM时抑制率为50%），并且在体外显示出较强的抗疟活性，IC50为25 nM。
