Dou J, McChesney J D, Sindelar R D, Goins D K, Walker L A
Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, University of Mississippi, University 38677, USA.
J Nat Prod. 1996 Jan;59(1):73-6. doi: 10.1021/np960013j.
A new quassinoid, 11-O-trans-p-coumaroyl amarolide (1) was isolated from Castela texana, and the structure was elucidated by spectroscopic analysis. Compound 1 is the first coumaroyl quassinoid derivative to have been isolated from nature. The known compounds amarolide (2), chaparrinone, chaparrin, glaucarubolone, holacanthone, and 15-O-beta-D-glucopyranosyl glaucarubol were also isolated. All isolated compounds were tested for their cytotoxicity and antiprotozoal activities.
从德克萨斯卡斯泰拉中分离出一种新的苦木素类化合物11 - O -反式对香豆酰阿玛罗内酯（1），并通过光谱分析阐明了其结构。化合物1是从自然界中分离得到的首个香豆酰苦木素类衍生物。还分离出了已知化合物阿玛罗内酯（2）、查帕里诺酮、查帕里宁、格劳卡鲁波酮、霍拉坎酮以及15 - O -β - D -吡喃葡萄糖基格劳卡鲁波醇。对所有分离出的化合物进行了细胞毒性和抗原虫活性测试。
