Cullen J J, Hemann L L, Ephgrave K S, Hinkhouse M M
Department of Surgery, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City, Iowa, USA.
J Gastrointest Surg. 1997 May-Jun;1(3):286-91. doi: 10.1016/s1091-255x(97)80122-9.
Enteral feeding during and after episodes of sepsis may be beneficial. The aim of our study was to determine the effects of a single sublethal dose of endotoxin on canine jejunal absorption. Following a 240 kcal liquid meal, absorption studies were performed in eight dogs with 75 cm jejunal Thiry-Vella fistulas. These fistulas were perfused with an isotonic solution containing polyethylene glycol to calculate absorption. Each dog was then given a single dose of Escherichia coli lipopolysaccharide, 200 microg/kg intravenously, and the studies were repeated for the next 3 days. Following endotoxin bolus infusion, net absorption of water, electrolytes, and glucose was decreased for 2 days and returned to baseline values on postendotoxin day 3. A single sublethal dose of endotoxin temporarily impairs canine jejunal absorption. Although enteral feeding may be advantageous, jejunal absorption may be temporarily impaired following an episode of endotoxemia.
脓毒症发作期间及之后进行肠内喂养可能有益。我们研究的目的是确定单次亚致死剂量内毒素对犬空肠吸收的影响。在给予240千卡液体餐之后，对8只具有75厘米空肠Thiry-Vella瘘管的犬进行吸收研究。用含有聚乙二醇的等渗溶液灌注这些瘘管以计算吸收情况。然后每只犬静脉注射单次剂量的大肠杆菌脂多糖，200微克/千克，并在接下来的3天重复进行研究。在内毒素推注后，水、电解质和葡萄糖的净吸收在2天内降低，并在内毒素注射后第3天恢复到基线值。单次亚致死剂量的内毒素会暂时损害犬空肠吸收。虽然肠内喂养可能有益，但在内毒素血症发作后空肠吸收可能会暂时受损。
