Singh K, Kumar S, Jaiswal M S, Chandra M, Singh M
Department of Surgery, King George's Medical College, Lucknow.
J Indian Med Assoc. 1998 Jun;96(6):177-8.
A prospective study was conducted in 26 patients with benign oral ulcers and oral carcinoma and 26 age and sex matched controls to determine the prevalence of Helicobacter pylori in oral mucosal biopsies. Oral mucosal biopsies were subjected to rapid urease test, campylobacter like organism (CLO) test, histopathological examination and bacteriological culture for demonstration of H pylori. Urease test was positive for H pylori in 3 (11.4%) out of 26 cases and CLO test in 2 (14%) out of 14 cases. On histology, H pylori was identified in 4 (15.38%) out of 26 cases. The spiral organism was universally absent in culture of both patients and controls. These pilot data negate the casual association of H pylori in oral mucosal lesions.
对26例患有良性口腔溃疡和口腔癌的患者以及26例年龄和性别匹配的对照者进行了一项前瞻性研究，以确定口腔黏膜活检中幽门螺杆菌的患病率。对口腔黏膜活检组织进行快速尿素酶试验、类弯曲菌（CLO）试验、组织病理学检查和细菌培养，以检测幽门螺杆菌。26例病例中有3例（11.4%）尿素酶试验呈幽门螺杆菌阳性，14例病例中有2例（14%）CLO试验呈阳性。组织学检查发现，26例病例中有4例（15.38%）存在幽门螺杆菌。患者和对照者的培养物中均未发现螺旋状生物体。这些初步数据否定了幽门螺杆菌与口腔黏膜病变之间的偶然关联。
