Schneider-Maunoury S, Gilardi-Hebenstreit P, Charnay P
Unité 368 de l'Inserm, Paris, France.
C R Acad Sci III. 1998 Oct;321(10):819-34. doi: 10.1016/s0764-4469(99)80022-5.
During vertebrate embryogenesis, the hindbrain is the site of a segmentation process which leads to the formation, along the anterior-posterior axis, of 7-8 metameres called rhombomeres. This phenomenon plays an essential role in early hindbrain regionalisation and in the specification of the pattern of developing structures in this region of the brain. Data accumulated during the last 10 years have also shown that rhombomeres are units of gene expression and of cell lineage. Hence, a number of regulatory genes are expressed according to segment-specific patterns in the hindbrain and have been implicated in the pattern formation process. In this review, we focus on the analysis of the function and regulation of these genes along the different steps of hindbrain segmentation, from segment delimitation to acquisition of positional identity. On this basis, we propose a model for the control of early hindbrain development.
在脊椎动物胚胎发育过程中，后脑是一个分节过程发生的部位，该过程沿着前后轴导致形成7 - 8个称为菱脑节的体节。这种现象在早期后脑区域化以及该脑区发育结构模式的特化中起着至关重要的作用。过去10年积累的数据还表明，菱脑节是基因表达和细胞谱系的单位。因此，许多调控基因以后脑节段特异性模式表达，并参与了模式形成过程。在这篇综述中，我们重点分析这些基因在从节段界定到获得位置身份的后脑分节不同步骤中的功能和调控。在此基础上，我们提出了一个早期后脑发育控制模型。
