Gui X Y
University of Sydney Department of Medicine, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
J Gastroenterol Hepatol. 1998 Oct;13(10):980-9. doi: 10.1111/j.1440-1746.1998.tb00558.x.
Intestinal mast cell activation (degranulation), which results from previous enteric infection and/or intestinal allergy, may play a central role in the gut hypersensitivity in both motor response and visceral perception in the Irritable Bowel syndrome. This occurs through various mediators acting on enteric neurons and smooth muscle cells. Psychological stress may trigger this sensitive alarm system via the brain-gut axis.
肠道肥大细胞激活（脱颗粒）由先前的肠道感染和/或肠道过敏引起，可能在肠易激综合征的肠道超敏反应中，在运动反应和内脏感觉方面发挥核心作用。这是通过多种作用于肠神经元和平滑肌细胞的介质发生的。心理压力可能通过脑-肠轴触发这个敏感的警报系统。
