Rosa Julia M, Formolo Douglas A, Yu Jiasui, Lee Thomas H, Yau Suk-Yu
Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China.
Mental Health Research Center (MHRC), Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China.
Front Behav Neurosci. 2022 Mar 1;16:828258. doi: 10.3389/fnbeh.2022.828258. eCollection 2022.
Depression and anxiety are devastating disorders. Understanding the mechanisms that underlie the development of depression and anxiety can provide new hints on novel treatments and preventive strategies. Here, we summarize the latest findings reporting the novel roles of gut microbiota and microRNAs (miRNAs) in the pathophysiology of depression and anxiety. The crosstalk between gut microbiota and the brain has been reported to contribute to these pathologies. It is currently known that some miRNAs can regulate bacterial growth and gene transcription while also modulate the gut microbiota composition, suggesting the importance of miRNAs in gut and brain health. Treatment and prevention strategies for neuropsychiatric diseases, such as physical exercise, diet, and probiotics, can modulate the gut microbiota composition and miRNAs expressions. Nonetheless, there are critical questions to be addressed to understand further the mechanisms involved in the interaction between the gut microbiota and miRNAs in the brain. This review summarizes the recent findings of the potential roles of microbiota and miRNA on the neuropathology of depression and anxiety, and its potential as treatment strategies.
抑郁症和焦虑症是极具破坏性的疾病。了解抑郁症和焦虑症发生发展的潜在机制可为新型治疗方法和预防策略提供新线索。在此，我们总结了关于肠道微生物群和微小RNA（miRNA）在抑郁症和焦虑症病理生理学中的新作用的最新研究发现。据报道，肠道微生物群与大脑之间的相互作用导致了这些病症。目前已知，一些miRNA可调节细菌生长和基因转录，同时还能调节肠道微生物群的组成，这表明miRNA对肠道和大脑健康具有重要意义。神经精神疾病的治疗和预防策略，如体育锻炼、饮食和益生菌，可调节肠道微生物群的组成和miRNA的表达。尽管如此，要进一步了解肠道微生物群与大脑中miRNA相互作用所涉及的机制，仍有一些关键问题有待解决。本综述总结了微生物群和miRNA在抑郁症和焦虑症神经病理学中的潜在作用的最新研究发现及其作为治疗策略的潜力。
