Larrick J W, Yu L, Chen J, Jaiswal S, Wycoff K
Palo Alto Institute of Molecular Medicine, Mountain View, CA 94043, USA.
Res Immunol. 1998 Jul-Aug;149(6):603-8. doi: 10.1016/s0923-2494(98)80013-8.
Plants offer a cost-effective bioreactor to produce antibodies of diverse types. Recent studies demonstrate that secretory IgA, the predominant antibody isotype of the mucosal immune system, can be made in large quantities in plants. CaroRx, the lead SIgA antibody being developed by Planet Biotechnology Inc., has demonstrated activity in pilot phase II trials versus S. mutans, the major pathogen contributing to development of dental caries. Numerous other SIgA plantibodies are in preclinical development.
植物提供了一种经济高效的生物反应器来生产多种类型的抗体。最近的研究表明，分泌型免疫球蛋白A（secretory IgA），即黏膜免疫系统的主要抗体同种型，可以在植物中大量生产。CaroRx是Planet Biotechnology Inc.正在研发的主要分泌型免疫球蛋白A抗体，已在针对变形链球菌（导致龋齿的主要病原体）的II期临床试验中显示出活性。许多其他分泌型免疫球蛋白A植物抗体正处于临床前开发阶段。
