头孢吡肟、头孢他啶和亚胺培南单独使用或与阿米卡星联合使用对由头孢他啶敏感或耐药的阴沟肠杆菌菌株引起的实验性肺炎大鼠的疗效。
Efficacies of cefepime, ceftazidime, and imipenem alone or in combination with amikacin in rats with experimental pneumonia due to ceftazidime-susceptible or -resistant Enterobacter cloacae strains.
作者信息
Mimoz O, Jacolot A, Leotard S, Hidri N, Samii K, Nordmann P, Petitjean O
机构信息
Service d'Anesthésie-Réanimation, Hôpital Paul Brousse, Assistance Publique-Hôpitaux de Paris, 94804 Villejuif Cedex, France.
出版信息
Antimicrob Agents Chemother. 1998 Dec;42(12):3304-8. doi: 10.1128/AAC.42.12.3304.
Abstract
The antibacterial activities of human regimens of cefepime, ceftazidime, and imipenem alone or in combination with amikacin against an isogenic pair of Enterobacter cloacae strains (wild type and its corresponding derepressed cephalosporinase mutant) were compared by using our nonlethal model of pneumonia with 180 immunocompetent rats. Compared with untreated animals, all beta-lactam-treated rats, except those inoculated with the mutant isolate and receiving ceftazidime, had significantly lower bacterial counts in their lungs 60 h after the onset of therapy. Although the combination of a beta-lactam and amikacin was more bactericidal than each corresponding antimicrobial agent alone, true synergy was noted only with cefepime and imipenem against the constitutive derepressed strain.
摘要
采用我们建立的180只免疫功能正常大鼠的非致死性肺炎模型，比较了头孢吡肟、头孢他啶和亚胺培南单独使用或与阿米卡星联合使用时，对阴沟肠杆菌同基因菌株对（野生型及其相应的去阻遏头孢菌素酶突变体）的抗菌活性。与未治疗的动物相比，除接种突变体分离株并接受头孢他啶治疗的大鼠外，所有接受β-内酰胺治疗的大鼠在治疗开始60小时后肺内细菌计数均显著降低。虽然β-内酰胺与阿米卡星联合使用比每种相应的抗菌剂单独使用更具杀菌作用，但仅在头孢吡肟和亚胺培南对组成型去阻遏菌株时观察到真正的协同作用。
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