几种二氨基甲基吡啶嘧啶对鸟分枝杆菌复合群的体外活性
In vitro activities of several diaminomethylpyridopyrimidines against Mycobacterium avium complex.
作者信息
Shoen C M, Choromanska O, Reynolds R C, Piper J R, Johnson C A, Cynamon M H
机构信息
Department of Medicine, Veterans Affairs Medical Center, Syracuse, New York, USA.
出版信息
Antimicrob Agents Chemother. 1998 Dec;42(12):3315-6. doi: 10.1128/AAC.42.12.3315.
Abstract
Three recently synthesized dihydrofolate reductase (DHFR) inhibitors designated SoRI 8890, 8895, and 8897 were evaluated for their in vitro activities against 25 isolates of Mycobacterium avium complex. The MICs at which 50 and 90% of isolates were inhibited were 1 and 2, 4 and 8, and 4 and 8 microgram/ml for SoRI 8890, 8895, and 8897, respectively. Although the addition of dapsone at 0.5 microgram/ml did not significantly enhance the in vitro activities of these compounds, their activities alone were comparable to, if not better than, results seen with other DHFR inhibitors, such as pyrimethamine or WR99210.
摘要
对最近合成的三种二氢叶酸还原酶（DHFR）抑制剂SoRI 8890、8895和8897进行了评估，以检测它们对25株鸟分枝杆菌复合群的体外活性。SoRI 8890、8895和8897抑制50%和90%分离株的最低抑菌浓度（MIC）分别为1和2、4和8以及4和8微克/毫升。虽然添加0.5微克/毫升的氨苯砜并未显著增强这些化合物的体外活性，但它们单独的活性即便不比其他DHFR抑制剂（如乙胺嘧啶或WR99210）更好，也与之相当。
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本文引用的文献
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