WR99210与氨苯砜联合使用时对鸟分枝杆菌复合群的体外活性增强。
Enhanced in vitro activity of WR99210 in combination with dapsone against Mycobacterium avium complex.
作者信息
Shah L M, DeStefano M S, Cynamon M H
机构信息
Veterans Affairs Medical Center, Syracuse, New York 13210, USA.
出版信息
Antimicrob Agents Chemother. 1996 Nov;40(11):2644-5. doi: 10.1128/AAC.40.11.2644.
Abstract
WR99210, a dihydrofolate reductase inhibitor, has promising in vitro activity against Mycobacterium avium complex (MAC). The in vitro activities of WR99210 alone and in combination with a fixed concentration of dapsone (0.5 microgram/ml) were evaluated against 35 clinical MAC isolates by a broth dilution method. The MIC at which 50% of isolates were inhibited (MIC50) and MIC90 of WR99210 alone were 2 and 8 micrograms/ml, respectively. The MIC50 and MIC90 of WR99210 in combination with dapsone were 0.25 and 4 micrograms/ml, respectively. Overall, 75% of the MAC isolates displayed enhanced susceptibility to the combination.
摘要
WR99210是一种二氢叶酸还原酶抑制剂，对鸟分枝杆菌复合群（MAC）具有良好的体外活性。采用肉汤稀释法评估了WR99210单独及与固定浓度（0.5微克/毫升）氨苯砜联合使用时对35株临床MAC分离株的体外活性。WR99210单独使用时，抑制50%分离株生长的最低抑菌浓度（MIC50）和MIC90分别为2微克/毫升和8微克/毫升。WR99210与氨苯砜联合使用时，MIC50和MIC90分别为0.25微克/毫升和4微克/毫升。总体而言，75%的MAC分离株对联合用药表现出更高的敏感性。
相似文献
1
Enhanced in vitro activity of WR99210 in combination with dapsone against Mycobacterium avium complex.WR99210与氨苯砜联合使用时对鸟分枝杆菌复合群的体外活性增强。
Antimicrob Agents Chemother. 1996 Nov;40(11):2644-5. doi: 10.1128/AAC.40.11.2644.
2
Enhanced in vitro activity of pyrimethamine in combination with dapsone against Mycobacterium avium complex.乙胺嘧啶联合氨苯砜对鸟分枝杆菌复合群的体外活性增强。
Antimicrob Agents Chemother. 1996 Oct;40(10):2426-7. doi: 10.1128/AAC.40.10.2426.
3
In-vitro activity of dapsone and two potentiators against Mycobacterium avium complex.
J Antimicrob Chemother. 1989 Jul;24(1):19-22. doi: 10.1093/jac/24.1.19.
4
In vitro activities of PS-15, a new dihydrofolate reductase inhibitor, and its cyclic metabolite against Mycobacterium avium complex.新型二氢叶酸还原酶抑制剂PS - 15及其环状代谢物对鸟分枝杆菌复合体的体外活性
Antimicrob Agents Chemother. 1995 Aug;39(8):1862-3. doi: 10.1128/AAC.39.8.1862.
5
In vitro activities of several diaminomethylpyridopyrimidines against Mycobacterium avium complex.几种二氨基甲基吡啶嘧啶对鸟分枝杆菌复合群的体外活性
Antimicrob Agents Chemother. 1998 Dec;42(12):3315-6. doi: 10.1128/AAC.42.12.3315.
6
In vitro activity of aminoglycosides, clofazimine, d-cycloserine and dapsone against 83 Mycobacterium avium complex clinical isolates.氨基糖苷类、氯法齐明、环丝氨酸和氨苯砜对 83 株鸟分枝杆菌复合体临床分离株的体外活性。
J Microbiol Immunol Infect. 2018 Oct;51(5):636-643. doi: 10.1016/j.jmii.2017.05.001. Epub 2017 Jun 28.
7
Activity of subinhibitory concentrations of dapsone alone and in combination with cell-wall inhibitors against Mycobacterium avium complex organisms.
Eur J Clin Microbiol Infect Dis. 1993 Dec;12(12):954-8. doi: 10.1007/BF01992173.
8
CI-960 (PD127391 or AM-1091), sparfloxacin, WIN 57273, and isepamicin activity against clinical isolates of Mycobacterium avium-intracellularae complex, M. chelonae, and M. fortuitum.CI-960（PD127391或AM-1091）、司帕沙星、WIN 57273及异帕米星对鸟分枝杆菌-胞内分枝杆菌复合体、龟分枝杆菌和偶然分枝杆菌临床分离株的活性。
Diagn Microbiol Infect Dis. 1992 Feb;15(2):169-71. doi: 10.1016/0732-8893(92)90044-t.
9
New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors.新型鸟分枝杆菌抗叶酸剂与二氢蝶酸合酶抑制剂联合使用时显示出协同效应。
Antimicrob Agents Chemother. 2005 Nov;49(11):4801-3. doi: 10.1128/AAC.49.11.4801-4803.2005.
10
In Vitro Susceptibility Testing of Bedaquiline against Mycobacterium avium Complex.贝达喹啉对鸟分枝杆菌复合群的体外药敏试验
Antimicrob Agents Chemother. 2017 Jan 24;61(2). doi: 10.1128/AAC.01798-16. Print 2017 Feb.
引用本文的文献
1
Mycobacterium tuberculosis folate metabolism and the mechanistic basis for para-aminosalicylic acid susceptibility and resistance.结核分枝杆菌的叶酸代谢以及对氨基水杨酸易感性和耐药性的机制基础。
Antimicrob Agents Chemother. 2015 Sep;59(9):5097-106. doi: 10.1128/AAC.00647-15. Epub 2015 Jun 1.
2
Antitubercular effect of 8-[(4-Chloro phenyl) sulfonyl]-7-Hydroxy-4-Methyl-2H-chromen-2-One in guinea pigs.8-[(4-氯苯基)磺酰基]-7-羟基-4-甲基-2H-色烯-2-酮对豚鼠的抗结核作用
J Pharmacol Pharmacother. 2011 Oct;2(4):253-60. doi: 10.4103/0976-500X.85951.
3
Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase.新型酿酒酵母筛选方法鉴定出可抑制结核分枝杆菌二氢叶酸还原酶的WR99210类似物。
Antimicrob Agents Chemother. 2002 Nov;46(11):3362-9. doi: 10.1128/AAC.46.11.3362-3369.2002.
4
In vitro activities of several diaminomethylpyridopyrimidines against Mycobacterium avium complex.几种二氨基甲基吡啶嘧啶对鸟分枝杆菌复合群的体外活性
Antimicrob Agents Chemother. 1998 Dec;42(12):3315-6. doi: 10.1128/AAC.42.12.3315.
5
Drug evaluation of concurrent Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium complex infections in a rat model.大鼠模型中卡氏肺孢子虫、弓形虫和鸟分枝杆菌复合群并发感染的药物评价
Antimicrob Agents Chemother. 1998 May;42(5):1068-72. doi: 10.1128/AAC.42.5.1068.
6
Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil.用人类二氢叶酸还原酶进行转化会使疟原虫对WR99210不敏感，但不会影响氯胍的内在活性。
Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10931-6. doi: 10.1073/pnas.94.20.10931.
本文引用的文献
1
2
Prophylaxis for opportunistic infections in patients with HIV infection.
Ann Intern Med. 1994 Jun 1;120(11):932-44. doi: 10.7326/0003-4819-120-11-199406010-00006.
3
Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone).
J Infect Dis. 1994 Feb;169(2):456-9. doi: 10.1093/infdis/169.2.456.
4
Activity of epiroprim (Ro 11-8958), a dihydrofolate reductase inhibitor, alone and in combination with dapsone against Toxoplasma gondii.
Antimicrob Agents Chemother. 1994 Aug;38(8):1803-7. doi: 10.1128/AAC.38.8.1803.
5
In vitro activities of PS-15, a new dihydrofolate reductase inhibitor, and its cyclic metabolite against Mycobacterium avium complex.新型二氢叶酸还原酶抑制剂PS - 15及其环状代谢物对鸟分枝杆菌复合体的体外活性
Antimicrob Agents Chemother. 1995 Aug;39(8):1862-3. doi: 10.1128/AAC.39.8.1862.
6
Sensitivity of Mycobacterium leprae to low levels of 4,4'-diaminodiphenyl sulfone.
Proc Soc Exp Biol Med. 1966 Jul;122(3):893-6. doi: 10.3181/00379727-122-31282.
7
Multiple-dose kinetics in healthy volunteers and in vitro antimalarial activity of proguanil plus dapsone.健康志愿者体内的多剂量动力学及氯胍加氨苯砜的体外抗疟活性
Chemotherapy. 1990;36(3):169-76. doi: 10.1159/000238763.
Zotero 插件