Esmerino L A, Ranali J, Rodrigues A L
Departamento de Ciências Fisiológicas, Faculdade de Odontologia de Piracicaba, UNICAMP, SP, Brasil.
Braz Dent J. 1998;9(1):33-7.
Normal and alloxan-diabetic rats were injected submucously in the posterior region of the upper jaw with bupivacaine (1.28 mg/kg) containing adrenaline (0.0012 mg/kg), or lignocaine (5.14 mg/kg) containing noradrenaline (0.005 mg/kg). Blood glucose was determined at zero (before administration), 0.5, 1, 2, 3 and 4 hours after the administration of the anesthetics. Statistical analysis (ANOVA and Tukey's test, P < 0.05) showed significant differences between treatments at 1 hour in normal rats. Bupivacaine with adrenaline induced a significantly greater blood glucose level than lignocaine with noradrenaline. The effect was significant but of short duration. In alloxan-diabetic rats, anesthetics containing adrenaline or noradrenaline did not induce increased blood glucose levels.
将含有肾上腺素（0.0012毫克/千克）的布比卡因（1.28毫克/千克）或含有去甲肾上腺素（0.005毫克/千克）的利多卡因（5.14毫克/千克）经黏膜下注射到正常大鼠和四氧嘧啶糖尿病大鼠的上颌后部区域。在麻醉剂给药后0（给药前）、0.5、1、2、3和4小时测定血糖。统计分析（方差分析和图基检验，P<0.05）显示，正常大鼠在给药1小时后各处理组之间存在显著差异。含肾上腺素的布比卡因诱导的血糖水平显著高于含去甲肾上腺素的利多卡因。这种作用显著但持续时间短。在四氧嘧啶糖尿病大鼠中，含肾上腺素或去甲肾上腺素的麻醉剂不会诱导血糖水平升高。
