Buczko W, Popow J
Acta Physiol Pol. 1976 Jul-Aug;27(4):387-94.
Trypsin in a dose of 5 mg/kg had no significant effect on tumour growth. Given simultaneously with cyclophosphamide the enzyme was found to reduce considerably the weight of tumours and to decrease the levels of DNA and RNA as compared with the group of animals receiving only cyclosphosphamide. These effects were correlated with histological examinations of tumour tissue. Trypsin was also shown to prevent the development of toxic effects of cyclophosphamide on the haemopoetic system. Probable mechanisms of the observed changes are discussed.
剂量为5毫克/千克的胰蛋白酶对肿瘤生长没有显著影响。与环磷酰胺同时给药时，发现该酶与仅接受环磷酰胺的动物组相比，能显著减轻肿瘤重量并降低DNA和RNA水平。这些效应与肿瘤组织的组织学检查结果相关。胰蛋白酶还被证明可预防环磷酰胺对造血系统的毒性作用。文中讨论了观察到的这些变化的可能机制。
