Carpenter M A, Brown E W, MacDonald D W, O'brien S J
SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland, 21702-1201, USA.
Virology. 1998 Nov 25;251(2):234-43. doi: 10.1006/viro.1998.9402.
Feline immunodeficiency virus (FIV) has a worldwide distribution among feral and domesticated cats and in many cases induces immunodeficiency disease analogous to that of human acquired immune deficiency syndrome. FIV is genetically homologous to human immunodeficiency virus (HIV) in both genome organization and gene sequence and, like HIV, exhibits enormous sequence variation throughout the range of host species. We sampled 91 feral cats from six disparate locales and studied the phylogenetic relationships of viral DNA from infected cats using both pol and env genes (520 and 684 bp, respectively). The patterns from the two genes recapitulated previously described major FIV clades and showed concordance between phylogenetic patterns of the pol and env genes. Evidence for recombination between the pol and env genes was not found among a sampling of nine isolates, although evidence for intragenic exchange within the env gene was observed in two isolates. A small local population of cats from a rural farm in the United Kingdom had a remarkably high FIV antibody prevalence (47%), but displayed 8-fold less overall diversity of FIV genomic variation compared with FIV from different parts of the world. We interpret this low variation as a consequence of a recent monophyletic introduction of FIV into the population.
猫免疫缺陷病毒（FIV）在野生和家养猫中广泛分布于全球，在许多情况下会引发类似于人类获得性免疫缺陷综合征的免疫缺陷疾病。FIV在基因组组织和基因序列上与人类免疫缺陷病毒（HIV）具有遗传同源性，并且与HIV一样，在整个宿主物种范围内表现出巨大的序列变异。我们从六个不同地点采集了91只野猫样本，并使用pol和env基因（分别为520和684 bp）研究了受感染猫的病毒DNA的系统发育关系。这两个基因的模式概括了先前描述的主要FIV分支，并显示了pol和env基因的系统发育模式之间的一致性。在九个分离株的样本中未发现pol和env基因之间重组的证据，尽管在两个分离株中观察到env基因内的基因内交换证据。来自英国一个乡村农场的一小群当地猫的FIV抗体患病率非常高（47%），但与来自世界不同地区的FIV相比，其FIV基因组变异的总体多样性低8倍。我们将这种低变异解释为FIV最近单系引入该种群的结果。
