Dunphy J T, Linder M E
Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, USA.
Biochim Biophys Acta. 1998 Dec 8;1436(1-2):245-61. doi: 10.1016/s0005-2760(98)00130-1.
Covalent lipid modifications anchor numerous signalling proteins to the cytoplasmic face of the plasma membrane. These modifications mediate protein-membrane and protein-protein interactions and are often essential for function. Protein palmitoylation, due to its reversible nature, may be particularly important for modulating protein function during cycles of activation and deactivation. Despite intense investigation, the exact functions of protein palmitoylation are not well understood. However, it is clear that palmitoylation can affect a protein's affinity for membranes, subcellular localization, and interactions with other proteins. In this review, recent advances in understanding the functions and mechanisms of protein palmitoylation are discussed, with particular emphasis on how this lipid affects the biochemistry and cell biology of signalling proteins.
共价脂质修饰将众多信号蛋白锚定在质膜的胞质面。这些修饰介导蛋白质与膜以及蛋白质与蛋白质之间的相互作用，并且通常对功能至关重要。蛋白质棕榈酰化由于其可逆性，在激活和失活循环过程中对调节蛋白质功能可能尤为重要。尽管进行了深入研究，但蛋白质棕榈酰化的确切功能仍未得到充分理解。然而，很明显棕榈酰化会影响蛋白质对膜的亲和力、亚细胞定位以及与其他蛋白质的相互作用。在这篇综述中，我们讨论了在理解蛋白质棕榈酰化的功能和机制方面的最新进展，特别强调了这种脂质如何影响信号蛋白的生物化学和细胞生物学。
