信号蛋白的可逆棕榈酰化

Reversible palmitoylation of signaling proteins.

作者信息

Mumby S M

机构信息

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75235-9041, USA.

出版信息

Curr Opin Cell Biol. 1997 Apr;9(2):148-54. doi: 10.1016/s0955-0674(97)80056-7.

DOI:10.1016/s0955-0674(97)80056-7

PMID:9069258

Abstract

Palmitoylation is unique among lipid modifications of proteins in that it is reversible and regulable. Recent advances in the study of palmitoylation include the following: the correlation of this modification with the localization of a signaling protein to specific membrane subdomains; the demonstration of a specific protein-protein interaction that is promoted by palmitoylation; and the identification, characterization, and purification of enzymes catalyzing this modification.

摘要

棕榈酰化在蛋白质的脂质修饰中独具特色，因为它是可逆且可调控的。棕榈酰化研究的最新进展包括：这种修饰与信号蛋白定位于特定膜亚结构域之间的关联；棕榈酰化促进特定蛋白质-蛋白质相互作用的证明；以及催化这种修饰的酶的鉴定、表征和纯化。