Buczko W
Acta Neurobiol Exp (Wars). 1976;36(4):447-54.
A mixture of fibrinopeptides A and B did not evoke any significant central effects when given by intraperitoneal injection, whereas it increased psychomotor activity when injected into a cerebral ventricle. The fibrinopeptides when given by intraperitoneal injection interacted with amphetamine to increase locomotor activity and with chlorpromazine to decrease both locomotor activity and body temperature. It is suggested that the release of fibrinopeptides in various clinical conditions where there is increased fibrinogen-fibrin conversion may lead to an altered sensitivity to centrally acting drugs.
纤维蛋白肽A和B的混合物经腹腔注射给药时未引起任何显著的中枢效应，而注入脑室时则会增加精神运动活性。纤维蛋白肽经腹腔注射给药时，与苯丙胺相互作用可增加运动活性，与氯丙嗪相互作用可降低运动活性和体温。有人提出，在纤维蛋白原-纤维蛋白转化增加的各种临床情况下，纤维蛋白肽的释放可能导致对中枢作用药物的敏感性改变。
