大鼠实验性肾血管夹性高血压中肾前列腺素的合成
Renal prostaglandin synthesis in experimental renal clip hypertension in the rat.
作者信息
Pugsley D, Beilin L, Peto R
出版信息
Adv Prostaglandin Thromboxane Res. 1976;2:595-8.
PMID:983862
Abstract
- The hypothesis that suppression of prostaglandin E (PGE) synthesis by indomethacin exacerbates renal clip hypertension in the rat was investigated. 2. Indomethacin exacerbated hypertension in renal clip rats. 3. In vitro PGE synthesis determined by gas liquid chromatography (GLC) was suppressed in medullary tissue from the hypertensive animals irrespective of indomethacin treatment. 4. The findings support the concept that PGs participate in blood pressure regulation in experimental renal hypertension.
摘要
- 研究了消炎痛抑制前列腺素E（PGE）合成会加剧大鼠肾血管夹闭性高血压这一假说。2. 消炎痛使肾血管夹闭大鼠的高血压加剧。3. 无论是否用消炎痛治疗，通过气液色谱法（GLC）测定的高血压动物髓质组织中的体外PGE合成均受到抑制。4. 这些发现支持了前列腺素参与实验性肾性高血压血压调节的概念。
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