Yuasa K, Shimizu T, Matsubara J, Toyoda T
Department of Thoracic and Cardiovascular Surgery, Kanazawa Medical University, Ishikawa, Japan.
Kyobu Geka. 1998 Nov;51(12):1001-5.
We used fibrin adhesive for the treatment of pulmonary air leak after pneumonectomy to sealing effect of fibrin adhesive which was classified by application and obtained the following results. 98 patients with pulmonary air leak were randomly allocated to the double layer group and spray group. The following were investigated between the double layer group and spray group. 1) size and dose of fibrin adhesive, 2) airway pressure where pulmonary air leak was observed before and after application, 3) duration of postoperative pulmonary air leak, 4) degree of postoperative pulmonary air leak, and 5) postoperative complication. The dose of fibrin adhesives was significantly smaller, the mean duration of postoperative pulmonary air leak was significantly shorter and the degree of postoperative pulmonary air leak was significantly more slight in the spray group than in the double layer group. In addition, the sutured part was examined before and after application of fibrin adhesives with a scanning electron microscope. Fibrin nets were formed more uniformly by the spray method than by the double layer method. From these investigations it is concluded that since the appliance for the spray method is improved and easily used and fibrin nets are formed uniformly by this method, the spray method is useful for the prophylaxis of pulmonary air leak.
我们使用纤维蛋白粘合剂治疗肺切除术后的肺漏气，根据应用方式对纤维蛋白粘合剂的封闭效果进行分类，并得出以下结果。98例肺漏气患者被随机分为双层组和喷雾组。对双层组和喷雾组进行了以下调查：1）纤维蛋白粘合剂的用量和剂量；2）应用前后观察到肺漏气时的气道压力；3）术后肺漏气持续时间；4）术后肺漏气程度；5）术后并发症。喷雾组纤维蛋白粘合剂的剂量明显更小，术后肺漏气的平均持续时间明显更短，术后肺漏气程度明显更轻。此外，在应用纤维蛋白粘合剂前后，用扫描电子显微镜检查缝合部位。喷雾法比双层法形成的纤维蛋白网更均匀。从这些研究得出结论，由于喷雾法的器械得到改进且易于使用，并且通过该方法能均匀形成纤维蛋白网，所以喷雾法对预防肺漏气是有用的。
