Omote Y, Kubo Y
Department of Surgery, Memuro County Hospital, Hokkaido, Japan.
Kyobu Geka. 1994 May;47(5):355-9.
The authors investigated the effectiveness of fibrin glue in preventing pulmonary air leakage after lung surgery. We first examined 29 patients who underwent pulmonary resection without the use of fibrin glue. On the basis of preoperative spirometry data, these patients were divided into normal respiratory function and poor function groups (%VC < 80% and/or FEV1.0% < 70%), and the duration of postoperative pulmonary air leakage in each group was studied. The duration was 2.2 +/- 1.4 days (mean +/- S.D, n = 18) in the normal group and 5.2 +/- 4.3 days (mean +/- S.D, n = 11) in the poor respiratory function group. The latter values were significantly greater than the former (p < 0.05, unpaired t-test). Then we examined seven patients who underwent lung surgery with the use of fibrin glue. We found that in three patients with normal respiratory function, the air leakage disappeared within one day, and in four patients who had poor respiratory function, the air leakage disappeared in three days. In both respiratory function groups, the air leakage seemed to disappear more quickly with the use of fibrin glue. These results suggest that fibrin glue is effective in preventing pulmonary air leakage.
作者研究了纤维蛋白胶在预防肺手术后肺漏气方面的有效性。我们首先检查了29例未使用纤维蛋白胶进行肺切除的患者。根据术前肺活量测定数据，将这些患者分为呼吸功能正常组和功能较差组（%VC<80%和/或FEV1.0%<70%），并研究了每组术后肺漏气的持续时间。正常组的持续时间为2.2±1.4天（平均值±标准差，n = 18），呼吸功能较差组为5.2±4.3天（平均值±标准差，n = 11）。后者的值明显大于前者（p<0.05，成组t检验）。然后我们检查了7例使用纤维蛋白胶进行肺手术的患者。我们发现，在3例呼吸功能正常的患者中，漏气在1天内消失，在4例呼吸功能较差的患者中，漏气在3天内消失。在两个呼吸功能组中，使用纤维蛋白胶后漏气似乎消失得更快。这些结果表明纤维蛋白胶在预防肺漏气方面是有效的。
