Okumura M, Tagami M, Fujinaga T
Graduate School of Veterinary Medicine, Hokkaido University, Japan.
Zentralbl Veterinarmed A. 1998 Oct;45(8):513-6. doi: 10.1111/j.1439-0442.1998.tb00854.x.
Keratan sulphate (KS) concentration and anticollagen type II antibody levels were measured in the serum and synovial fluid (SF) of clinically normal horses and horses with osteoarthritis (OA). Serum KS in OA was significantly higher than that in normal horses, while no significant difference was found in KS levels of SF between normal and OA. Assays of antibody to collagen type II showed no significant increase in sera and SF of OA. It was suggested that levels of serum KS would be of value in the pathological detection of OA in the joint, although there was no evidence that the measurable autoimmunity to collagen antigens would reflect the process of OA.
在临床正常马匹和骨关节炎（OA）马匹的血清及滑液（SF）中测量了硫酸角质素（KS）浓度和抗II型胶原抗体水平。OA马匹血清中的KS显著高于正常马匹，而正常马匹和OA马匹的滑液KS水平未发现显著差异。对II型胶原抗体的检测显示，OA马匹的血清和滑液中抗体无显著增加。结果表明，血清KS水平在关节OA的病理检测中具有一定价值，尽管没有证据表明可检测到的针对胶原抗原的自身免疫反应能反映OA的进程。
