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1
Phosphohexose isomerase (PHI) and porcine halothane sensitivity.磷酸己糖异构酶（PHI）与猪的氟烷敏感性
Acta Vet Scand. 1976;17(3):370-2. doi: 10.1186/BF03547918.
2
Close linkage established between the HAL locus for halothane sensitivity and the PHI (phosphohexose isomerase) locus in pigs of the Danish Landrace breed.在丹麦长白猪品种中，建立了氟烷敏感性的HAL基因座与PHI（磷酸己糖异构酶）基因座之间的紧密连锁关系。
Nord Vet Med. 1977 Nov;29(11):502-4.
3
Relationships between the H and A-O blood types, phosphohexose isomerase and 6-phosphogluconate dehydrogenase red cell enzyme systems and halothane sensitivity, and economic traits in a superior and an inferior selection line of swiss landrace pigs.
J Anim Sci. 1984 Dec;59(6):1440-50. doi: 10.2527/jas1984.5961440x.
4
Noneffectiveness of verapamil in preventing halothane-induced malignant hyperthermia in susceptible swine.维拉帕米对预防易感猪氟烷诱导的恶性高热无效。
Am J Vet Res. 1984 May;45(5):935-7.
5
Halothane sensitivity, the H blood group system and phosphohexose isomerase (PHI) in pigs. A linkage study of physiological importance.猪的氟烷敏感性、H血型系统与磷酸己糖异构酶（PHI）。一项具有生理重要性的连锁研究。
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6
Halothane sensitivity and linkage of genes for H red blood cell antigens, phosphohexose isomerase (PHI) and 6-phosphogluconate dehydrogenase (6-PGD) variants in pigs.猪中氟烷敏感性以及H红细胞抗原、磷酸己糖异构酶（PHI）和6 - 磷酸葡萄糖酸脱氢酶（6 - PGD）变体基因的连锁关系
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7
Anaesthesia in the pig.
Aust Vet J. 1973 Oct;49(10):474-7. doi: 10.1111/j.1751-0813.1973.tb09297.x.
8
Influence of nutrition on malignant hyperthermia in pigs.营养对猪恶性高热的影响。
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9
Precautions when using halothane.使用氟烷时的注意事项。
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10
The halothane sensitivity locus and its linkage relationships.氟烷敏感性基因座及其连锁关系。
Anim Blood Groups Biochem Genet. 1985;16(4):253-63. doi: 10.1111/j.1365-2052.1985.tb01478.x.

引用本文的文献

1
Etiopathogenetic defect of malignant hyperthermia: hypersensitive calcium-release channel of skeletal muscle sarcoplasmic reticulum.恶性高热的病因病理缺陷：骨骼肌肌浆网的超敏钙释放通道。
Vet Res Commun. 1987;11(6):527-59. doi: 10.1007/BF00396370.
2
Halothane sensitivity, the H blood group system and phosphohexose isomerase (PHI) in pigs. A linkage study of physiological importance.猪的氟烷敏感性、H血型系统与磷酸己糖异构酶（PHI）。一项具有生理重要性的连锁研究。
Acta Vet Scand. 1978;19(3):458-60. doi: 10.1186/BF03547614.

本文引用的文献

1
Pale, soft exudative pork, porcine stress syndrome and malignant hyperpyrexia--an identity?
J S Afr Vet Assoc. 1972 Mar;43(1):57-63.
2
H blood types in pigs as predictors of stress susceptibility.猪的H血型作为应激易感性的预测指标。
Science. 1976 Mar 5;191(4230):947-8. doi: 10.1126/science.1251204.

磷酸己糖异构酶（PHI）与猪的氟烷敏感性

Phosphohexose isomerase (PHI) and porcine halothane sensitivity.

作者信息

Jørgensen Preben Fogd, Hyldgaard-Jensen Jens, Moustgaard Johs., Eikelenboom G

机构信息

The Department of Physiology, Endocrinology and Bloodgrouping, Royal Veterinary and Agricultural University, Copenhagen, Denmark.

出版信息

Acta Vet Scand. 1976;17(3):370-2. doi: 10.1186/BF03547918.

DOI:10.1186/BF03547918
PMID:983897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8383953/
Abstract

Malignant hyperthermia is a serious consequence of halo-thane anaesthesia in predisposed animals and humans. In view of the similar clinical-biochemical symptoms in humans as well as in pigs susceptible to halothane anaesthesia, the stress susceptible pig appears to be a useful animal model for study of this abnormal condition and for development of non-destructive detection methods for its identification.

摘要

恶性高热是易感动物和人类接受氟烷麻醉后的严重后果。鉴于人类以及对氟烷麻醉敏感的猪具有相似的临床生化症状，应激易感猪似乎是研究这种异常情况以及开发用于识别它的非破坏性检测方法的有用动物模型。