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Interleukin-10 functions as an antiinflammatory cytokine in rheumatoid synovium.白细胞介素-10在类风湿性滑膜中作为一种抗炎细胞因子发挥作用。
Arthritis Rheum. 1996 Mar;39(3):386-95. doi: 10.1002/art.1780390306.
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Interleukin-10-deficient mice develop chronic enterocolitis.白细胞介素-10缺陷型小鼠会患上慢性小肠结肠炎。
Cell. 1993 Oct 22;75(2):263-74. doi: 10.1016/0092-8674(93)80068-p.
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Modulation of macrophage function by transforming growth factor beta, interleukin-4, and interleukin-10.转化生长因子β、白细胞介素-4和白细胞介素-10对巨噬细胞功能的调节
Ann N Y Acad Sci. 1993 Jun 23;685:713-39. doi: 10.1111/j.1749-6632.1993.tb35934.x.
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TGF-beta expression in the human colon: differential immunostaining along crypt epithelium.转化生长因子-β在人结肠中的表达：沿隐窝上皮的差异免疫染色
Br J Cancer. 1993 Jul;68(1):137-9. doi: 10.1038/bjc.1993.301.
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Interleukin-10 inhibits the primary allogeneic T cell response to human epidermal Langerhans cells.白细胞介素-10抑制原发性同种异体T细胞对人表皮朗格汉斯细胞的反应。
Eur J Immunol. 1994 Apr;24(4):884-91. doi: 10.1002/eji.1830240416.
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Antigen presentation in the central nervous system. The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed.中枢神经系统中的抗原呈递。白细胞介素-10对主要组织相容性复合体II类分子表达及细胞因子产生的抑制作用取决于诱导信号及所分析的细胞类型。
J Immunol. 1994 Mar 15;152(6):2720-8.
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Stimulation of lamina propria lymphocytes by intestinal epithelial cells: evidence for recognition of nonclassical restriction elements.肠上皮细胞对固有层淋巴细胞的刺激：识别非经典限制性元件的证据。
J Exp Med. 1994 Mar 1;179(3):943-50. doi: 10.1084/jem.179.3.943.
8
Interactions between interferon gamma and retinoic acid with transforming growth factor beta in the induction of immune recognition molecules.干扰素γ和视黄酸与转化生长因子β在免疫识别分子诱导过程中的相互作用。
Cancer Immunol Immunother. 1993 Jul;37(2):112-8. doi: 10.1007/BF01517043.
9
Properties and functions of interleukin-10.白细胞介素-10的特性与功能。
Adv Immunol. 1994;56:1-26.
10
Human colonocytes in primary culture: a model to study epithelial growth, metabolism and differentiation.原代培养的人结肠上皮细胞：一种用于研究上皮生长、代谢和分化的模型。
Int J Colorectal Dis. 1994 Apr;9(1):13-22. doi: 10.1007/BF00304294.

白细胞介素-10和转化生长因子β-1对结肠上皮细胞中HLA-DR表达的影响。

The effect of interleukin-10 and transforming growth factor beta-1 on HLA-DR expression in colonic epithelial cells.

作者信息

Zimmerman M J, Radford-Smith G R, Jewell D P

机构信息

Gastroenterology Department, Royal Perth Hospital, Western Australia, Australia.

出版信息

Mediators Inflamm. 1998;7(1):7-11. doi: 10.1080/09629359891315.

DOI:10.1080/09629359891315
PMID:9839692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1781823/
Abstract

The aim of this study was to assess whether interleukin-10 (IL-10) and/or transforming growth factor beta-1 (TGFbeta1) downregulate HLA-DR expression using the HT29 cell line as a model of colonic epithelial cells. HLA-DR expression was induced in HT29 cells with gamma-interferon. The effects of IL-10 alone, TGFbeta1 alone, and IL-10 and TGFbeta1 in combination were studied. HLA-DR expression was assessed using flow cytometric analysis. Gamma-interferon induced HLA-DR expression in a dose-dependent fashion. In the absence of gamma-interferon, neither IL-10 nor TGFbeta1 induced HLA-DR expression. In isolation, neither IL-10 nor TGFbeta1 downregulated HLA-DR expression. When IL-10 and TGFbeta1 were added in combination, small (6-30%) statistically significant reductions in HLA-DR expression were seen. The biological significance is unclear.

摘要

本研究的目的是使用HT29细胞系作为结肠上皮细胞模型，评估白细胞介素-10（IL-10）和/或转化生长因子β-1（TGFβ1）是否下调HLA-DR表达。用γ干扰素诱导HT29细胞中的HLA-DR表达。研究了单独的IL-10、单独的TGFβ1以及IL-10和TGFβ1联合使用的效果。使用流式细胞术分析评估HLA-DR表达。γ干扰素以剂量依赖性方式诱导HLA-DR表达。在没有γ干扰素的情况下，IL-10和TGFβ1均未诱导HLA-DR表达。单独使用时，IL-10和TGFβ1均未下调HLA-DR表达。当联合添加IL-10和TGFβ1时，观察到HLA-DR表达有小幅度（6%-30%）的统计学显著降低。其生物学意义尚不清楚。