Clery D G, Mulcahy G
Department of Veterinary Microbiology and Parasitology, University College Dublin, Ballsbridge, Ireland.
Res Vet Sci. 1998 Sep-Oct;65(2):169-71. doi: 10.1016/s0034-5288(98)90171-0.
An experiment was designed to characterise the early immune responses of cattle given a trickle infection of the trematode Fasciola hepatica. Lymphocyte responses and IFNgamma production following stimulation with Fasciola antigens were measured. Animals were sequentially slaughtered at weeks 5, 7, 9 and 11 post-infection. Results demonstrated responses to fluke antigens and cytokine production (IFNgamma) from weeks 2-5 post-infection. These findings may suggest an early stimulation of IFNgamma production by peripheral blood lymphocytes following infection with F hepatica in cattle.
设计了一项实验来表征经肝片吸虫微量感染的牛的早期免疫反应。测定了用肝片吸虫抗原刺激后的淋巴细胞反应和γ干扰素产生情况。在感染后第5、7、9和11周依次宰杀动物。结果表明，在感染后第2至5周对吸虫抗原产生了反应并产生了细胞因子（γ干扰素）。这些发现可能表明牛感染肝片吸虫后外周血淋巴细胞对γ干扰素产生有早期刺激作用。
