Stahl S M
Department of Psychiatry, University of California San Diego and Clinical Neuroscience Research Center, 92122, USA.
J Clin Psychiatry. 1998;59 Suppl 18:23-9.
The diversity of antidepressant mechanisms available today allows clinicians to individualize treatment decisions for depressive symptoms and subtypes, as well as to avoid side effects. The mechanism of action of antidepressants allows prediction of both adverse effects and therapeutic effects. Individual antidepressants have unique psychopharmacologic profiles, and individual patients have unique clinical profiles of different symptoms and depressive subtypes. By using this knowledge, the prescriber can match drug profiles with patient profiles to select preferred agents and avoid less preferred agents.
如今可用的抗抑郁药作用机制具有多样性，这使临床医生能够针对抑郁症状和亚型进行个体化治疗决策，并避免副作用。抗抑郁药的作用机制有助于预测不良反应和治疗效果。每种抗抑郁药都有独特的精神药理学特征，而每个患者对于不同症状和抑郁亚型也有独特的临床特征。通过运用这些知识，开处方的医生可以将药物特征与患者特征相匹配，以选择更合适的药物并避免选用不太合适的药物。
