Brehler R, Voss W, Müller S
Department of Dermatology, University of Münster, Germany.
Contact Dermatitis. 1998 Nov;39(5):227-30. doi: 10.1111/j.1600-0536.1998.tb05914.x.
Most patients with immediate-type-hypersensitivity to natural rubber latex (NRL) give a history of hand eczema. Susceptibility to allergens is increased by irritant hand eczema due to damage to the skin barrier. Therefore, especially for employees in medical or paramedical professions, reduction in skin irritation is of importance. The present study reports the effect of glove powder on skin roughness, one feature of skin irritancy. Skin replicas, performed before and after wearing different types of gloves, were evaluated by laser profilometry. Significant alteration of skin roughness was evident and determined by different factors. Use of unpowdered Biogel gloves on prepowdered hands results in an increase in skin roughness, in contrast to the use of Biogel gloves on hands without any pre-application. On the other hand, powdered Manex neoderm gloves show no influence on the skin structure, whereas powdered Peha taft gloves also increase the roughness of the skin. Other potential candidates causing skin morphology alteration could be the glove pH, rubber chemicals with irritant potential and other characteristics of gloves, which are already under investigation.
大多数对天然橡胶乳胶（NRL）有速发型超敏反应的患者都有手部湿疹病史。由于皮肤屏障受损，刺激性手部湿疹会增加对过敏原的易感性。因此，特别是对于医疗或辅助医疗行业的员工来说，减少皮肤刺激非常重要。本研究报告了手套粉末对皮肤粗糙度（皮肤刺激性的一个特征）的影响。通过激光轮廓测量法对手部佩戴不同类型手套前后制作的皮肤复制品进行评估。皮肤粗糙度的显著变化很明显，并且由不同因素决定。在预先涂粉的手上使用无粉的Biogel手套会导致皮肤粗糙度增加，这与在未预先涂粉的手上使用Biogel手套形成对比。另一方面，涂粉的Manex新皮肤手套对皮肤结构没有影响，而涂粉的Peha塔夫脱手套也会增加皮肤粗糙度。其他可能导致皮肤形态改变的潜在因素可能是手套的pH值、具有刺激潜力的橡胶化学物质以及手套的其他特性，这些因素已经在研究中。
