Lundell L, Dalenbäck J, Hattlebakk J, Janatuinen E, Levander K, Miettinen P, Myrvold H E, Pedersen S A, Thor K, Junghard O, Andersson A
Department of Surgery, Sahlgren's University Hospital, Göteborg, Sweden.
Eur J Surg. 1998 Oct;164(10):751-7. doi: 10.1080/110241598750005381.
To evaluate the outcome of antireflux surgery in various hospitals in Scandinavian countries.
Partly randomised controlled study, and partly open study.
Hospitals throughout Norway, Sweden, Denmark and Finland.
310 patients with chronic reflux disease and oesophagitis who were initially entered into a randomised controlled study of omeprazole and antireflux surgery.
Total fundic wrap, partial fundoplication, or omeprazole.
Control of symptoms at one year.
154 patients who had their symptoms of reflux completely controlled with omeprazole were initially randomised to have an open operation but 10 refused, leaving 144 for analysis. 34 patients who had only a partial response were also offered operation; 120/178 (68%) had a total fundic wrap, and 53 (30%) partial fundoplication. 6 patients had postoperative complications that required reoperation and 123 made a completely uneventful recovery. Reflux was controlled in most patients, and only 10 (6%) required further treatment with omeprazole. The outcome in those patients who only responded partially to omeprazole was similar to that in patients who had a complete response.
The outcome of antireflux surgery throughout Norway, Sweden, Denmark, and Finland is good.
评估斯堪的纳维亚国家各医院抗反流手术的疗效。
部分为随机对照研究，部分为开放性研究。
挪威、瑞典、丹麦和芬兰的各医院。
310例患有慢性反流病和食管炎的患者，他们最初被纳入奥美拉唑与抗反流手术的随机对照研究。
全胃底折叠术、部分胃底折叠术或奥美拉唑。
一年时症状的控制情况。
154例使用奥美拉唑后反流症状得到完全控制的患者最初被随机分配接受开放性手术，但10例拒绝，剩余144例用于分析。34例只有部分反应的患者也接受了手术；120/178（68%）接受了全胃底折叠术，53例（30%）接受了部分胃底折叠术。6例患者术后出现并发症需要再次手术，123例恢复顺利。大多数患者的反流得到控制，只有10例（6%）需要进一步使用奥美拉唑治疗。那些对奥美拉唑只有部分反应的患者的结果与有完全反应的患者相似。
挪威、瑞典、丹麦和芬兰各地抗反流手术的疗效良好。
