Miyahara H, Naito H, Ueda K, Yane K, Matsunaga T, Okaichi K, Ohnishi T
Department of Otolaryngology, Head and Neck Surgery, Nara Medical University, Kashihara, Japan.
Acta Otolaryngol. 1998 Sep;118(5):763-8. doi: 10.1080/00016489850183331.
We studied int-2 and bcl-1 gene amplification in 21 operated patients with cancer of the larynx. In 9 cases, the int-2 gene was amplified (42.9%) and in 4 cases. the bcl-1 gene was amplified (25.0%). Co-amplification of int-2 and bcl-1 was observed in three cases (18.8%), all of which were glottic carcinomas. Other amplified cases were supraglottic carcinomas. Tumor specimens with int-2 amplification were associated with a significantly worse prognosis. We suggest that int-2 amplification is one of the prognostic factors in laryngectomized patients with cancer of the larynx.
我们研究了21例接受手术的喉癌患者的int-2和bcl-1基因扩增情况。9例患者int-2基因发生扩增（42.9%），4例患者bcl-1基因发生扩增（25.0%）。3例患者（18.8%）观察到int-2和bcl-1基因共同扩增，所有这些患者均为声门癌。其他扩增病例为声门上癌。int-2基因扩增的肿瘤标本预后明显较差。我们认为int-2基因扩增是喉癌喉切除患者的预后因素之一。
