Liu S, Lin D, Hong B, Huang G
Hua Xi Yi Ke Da Xue Xue Bao. 1994 Mar;25(1):41-4.
C-myc amplification in 22 squamous cell carcinomas and 10 normal tissues (control) from the larynx was assessed by dot hybridization technique. Significant amplification of C-myc oncogene was found in malignant tumours as compared with the normal tissues. The extent of amplification also correlated with advanced tumour stages. There was a significant increase in C-myc amplification in TNM stages III and IV when compared with the stages I and II. These data suggested that C-myc oncogene might be activated by gene amplification and it might have a key role in determining the aggressiveness of laryngeal carcinoma.
采用点杂交技术评估了22例喉鳞状细胞癌及10例正常喉组织（对照）中C-myc基因的扩增情况。与正常组织相比，在恶性肿瘤中发现C-myc癌基因有显著扩增。扩增程度还与肿瘤晚期有关。与Ⅰ期和Ⅱ期相比，Ⅲ期和Ⅳ期TNM分期中C-myc扩增显著增加。这些数据表明，C-myc癌基因可能通过基因扩增被激活，并且可能在决定喉癌的侵袭性方面起关键作用。
