Obasi A, Mosha F, Quigley M, Sekirassa Z, Gibbs T, Munguti K, Todd J, Grosskurth H, Mayaud P, Changalucha J, Brown D, Mabey D, Hayes R
London School of Hygiene, Central Public Health Laboratory, London, United Kingdom.
J Infect Dis. 1999 Jan;179(1):16-24. doi: 10.1086/314555.
A serosurvey was conducted in a random sample of 259 women and 231 men in 12 rural communities in Mwanza Region, Tanzania, using a type-specific ELISA for Herpes simplex virus type 2 (HSV-2) infection. Seroprevalence rose steeply with age to approximately 75% in women >=25 years old and 60% in men >=30. After adjusting for age and residence, HSV-2 prevalence was higher in women who were married, in a polygamous marriage, Treponema pallidum hemagglutination assay (TPHA)-positive, had more lifetime sex partners, or who had not traveled. Prevalence was higher in men who were married, had lived elsewhere, had more lifetime partners, had used condoms, or were TPHA-positive. HSV-2 infection was significantly associated with recent history of genital ulcer. The association between HSV-2 infection and lifetime sex partners was strongest in those <25 years old in both sexes. This association supports the use of HSV-2 serology as a marker of risk behavior in this population, particularly among young people.
在坦桑尼亚姆万扎地区的12个农村社区，对259名女性和231名男性的随机样本进行了血清学调查，采用型特异性酶联免疫吸附测定法检测2型单纯疱疹病毒（HSV-2）感染情况。血清阳性率随年龄急剧上升，在25岁及以上女性中约为75%，在30岁及以上男性中约为60%。在调整年龄和居住地后，已婚、处于一夫多妻婚姻、梅毒螺旋体血凝试验（TPHA）呈阳性、有更多终身性伴侣或未出过远门的女性中，HSV-2感染率更高。已婚、曾在其他地方居住、有更多终身伴侣、使用过避孕套或TPHA呈阳性的男性中，感染率更高。HSV-2感染与近期生殖器溃疡病史显著相关。在25岁以下的男女中，HSV-2感染与终身性伴侣之间的关联最为强烈。这种关联支持将HSV-2血清学作为该人群，尤其是年轻人风险行为的一个指标。
