Müller U, Jochheim R, Knaup W, Tenholt M
Abteilung Innere Medizin, Klinik Blankenstein in Hattingen, Bochum.
Dtsch Med Wochenschr. 1998 Nov 13;123(46):1378-82. doi: 10.1055/s-2007-1024191.
A 52-year-old woman had for 31 years been experiencing occasional episodes of dizziness and syncope, as well as sudden attacks of "shaking" in the chest associated with cramp-like pain, nausea and weak spells, each lasting for up to 45 min. She had since childhood been suffering from atopy, with bronchial asthma and polyvalent allergies. On examination, which was otherwise unremarkable, her blood pressure was 140/100 mm Hg with a sinus tachycardia of 110/min. She was admitted for implantation of an event recorder to establish the etiology of the described symptoms.
The results of routine laboratory tests, including those of thyroid function, were within normal limits. The ECG showed sinus rhythm and minor left precordinal abnormalities of repolarization. The echocardiogram was normal and coronary angiography excluded coronary heart disease.
3 weeks after ambulatory implantation of an event recorder (Reveal, Medtronic) she again had an attack. The recorded ECG indicated a supraventricular tachycardia (190/min), preceded by an atrial extrasystole, lasting 3 min 14 s. She was treated with digitalis and verapamil, her asthma contraindicating solatol. She had refused further invasive diagnostic measures. The appearance of an allergic rash required a change of drugs to propafenon. But as this, too, was poorly tolerated, electrophysiological testing was undertaken. It revealed an AV nodal reentry tachycardia which was treated with local ablation: supraventricular extrasystoles continued to occur frequently, but there were no further episodes of reentry tachycardia.
In patients with recurrent syncopes, but otherwise unremarkable clinical findings, an implantable event recorder may provide important diagnostic information, especially relating to a possible arrhythmogenic cause.
一名52岁女性31年来偶尔出现头晕和晕厥发作,以及胸部突然发作的“震颤”,伴有痉挛样疼痛、恶心和虚弱感,每次发作持续长达45分钟。她自幼患有特应性疾病,有支气管哮喘和多种过敏症。体格检查未发现其他异常,血压为140/100 mmHg,窦性心动过速,心率110次/分钟。她因植入事件记录仪以明确上述症状的病因而入院。
包括甲状腺功能检查在内的常规实验室检查结果均在正常范围内。心电图显示窦性心律及左胸前导联轻微复极异常。超声心动图正常,冠状动脉造影排除冠心病。
动态植入事件记录仪(美敦力公司的Reveal)3周后,她再次发作。记录的心电图显示室上性心动过速(190次/分钟),发作前有房性期前收缩,持续3分14秒。因她患有哮喘,禁用索他洛尔,故给予洋地黄和维拉帕米治疗。她拒绝进一步的侵入性诊断措施。出现过敏皮疹后,改用普罗帕酮,但她对该药耐受性也较差,于是进行了电生理检查。结果显示为房室结折返性心动过速,采用局部消融治疗:室上性期前收缩仍频繁发生,但未再出现折返性心动过速发作。
对于反复晕厥但临床检查无其他明显异常的患者,植入式事件记录仪可能提供重要的诊断信息,尤其是与可能的心律失常病因相关的信息。