Sharkey L C, Holycross B J, Park S, McCune S A, Hoversland R, Radin M J
Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA.
Am J Physiol. 1998 Dec;275(6):R1968-76. doi: 10.1152/ajpregu.1998.275.6.R1968.
The importance of the loss of ovarian function to the progression of hypertension and heart disease in women is controversial. We investigated whether ovariectomy would accelerate development of hypertension, congestive heart failure, and neurohumoral activation in adult spontaneous hypertension heart failure (SHHF) rats, a genetic model of heart failure. Six months after ovariectomy, no significant differences between control and ovariectomized rats were seen in systolic or diastolic blood pressure, left ventricular fractional shortening by echocardiography, or heart weight. Percent V1 myosin isozyme was significantly lower in ovariectomized rats. Northern blot analysis failed to show significant differences between groups in expression of hepatic angiotensinogen, renal renin, or left ventricular atrial or brain natriuretic peptide mRNA. In a second experiment, serial measures of systolic pressure and left ventricular shortening fractions failed to document a significant difference between control and ovariectomized rats as they developed heart failure, although there was a significant decline in shortening fraction in both groups at the age when regular estrous cycling naturally ceases. Survival time was similar between groups. In summary, ovariectomy of adult SHHF rats does not appear to affect the progression of genetically programmed hypertension and heart failure in this model.
卵巢功能丧失对女性高血压和心脏病进展的重要性存在争议。我们研究了卵巢切除术是否会加速成年自发性高血压心力衰竭（SHHF）大鼠（一种心力衰竭的遗传模型）的高血压、充血性心力衰竭和神经体液激活的发展。卵巢切除术后6个月，对照组和卵巢切除组大鼠在收缩压或舒张压、超声心动图测量的左心室缩短分数或心脏重量方面均未观察到显著差异。卵巢切除组大鼠中V1肌球蛋白同工酶百分比显著降低。Northern印迹分析未显示两组在肝血管紧张素原、肾素或左心室心房或脑钠肽mRNA表达上有显著差异。在第二项实验中，尽管两组在自然规律发情周期停止的年龄时缩短分数均显著下降，但在对照组和卵巢切除组大鼠发生心力衰竭时，连续测量的收缩压和左心室缩短分数未显示出显著差异。两组的存活时间相似。总之，在该模型中，成年SHHF大鼠的卵巢切除术似乎不影响遗传性高血压和心力衰竭的进展。
