McDermott N C, Hayes D P, al-Sader M H, Hogan J M, Walsh C B, Kay E W, Leader M B
Department of Pathology, Royal College of Surgeons in Ireland, St Stephen's Green, Ireland.
Am J Clin Pathol. 1998 Dec;110(6):753-7. doi: 10.1093/ajcp/110.6.753.
Ninety-four H & E-stained slides of malignant melanoma were circulated to 6 pathologists in 2 university departments. For each slide, the growth phase of the lesion, Breslow thickness, and Clark level were determined by each observer. The aims of the study were to evaluate agreement between nonspecialist pathologists in identifying the vertical growth phase in malignant melanoma and to compare agreement for the growth phase with agreement for Breslow thickness and the Clark level. Our results show that although overall agreement for the growth phase is moderate, agreement between experienced observers is good. In fact agreement for the growth phase among this group was equal to the agreement for Breslow thickness. Overall agreement for Breslow thickness also was good but for the Clark level was only fair. These findings suggest that if the predictive value of the vertical growth phase proves to be robust, it will be used with an acceptable level of accuracy in routine diagnostic practice.
94张苏木精-伊红染色的恶性黑色素瘤玻片被分发给两所大学院系的6名病理学家。对于每张玻片，每位观察者都要确定病变的生长阶段、Breslow厚度和Clark分级。本研究的目的是评估非专科病理学家在识别恶性黑色素瘤垂直生长阶段方面的一致性，并比较生长阶段的一致性与Breslow厚度和Clark分级的一致性。我们的结果表明，虽然生长阶段的总体一致性中等，但有经验的观察者之间的一致性良好。事实上，该组中生长阶段的一致性与Breslow厚度的一致性相当。Breslow厚度的总体一致性也良好，但Clark分级的一致性仅为一般。这些发现表明，如果垂直生长阶段的预测价值被证明是可靠的，那么在常规诊断实践中它将以可接受的准确度被使用。
