活体小鼠体内器官的三维电子自旋共振（ESR）成像

Three dimensional electron spin resonance (ESR) imaging of internal organs in living mice.

作者信息

Masumizu T, Fujii K, Kohno M, Nagai S, Odagaki Y, Imanari M, Mori A, Packer L

机构信息

ESR Application Laboratory, Application & Research Center, Analytical Instruments Division, JEOL LTD., Tokyo, Japan.

出版信息

Biochem Mol Biol Int. 1998 Nov;46(4):707-17. doi: 10.1080/15216549800204242.

DOI:10.1080/15216549800204242

PMID:9844731

Abstract

In vivo electron spin resonance imaging (ESR imaging) was applied to living mice after peroral administration of a nitroxide radical spin probe. A 3D ESR imaging procedure was applied in vivo in order to obtain the exact distribution of the spin probe in a living animal. The imaging pictures demonstrated that the administered spin probe was firstly located in the stomach, then delivered to the liver, kidney and heart of the animal.

摘要

在给活体小鼠经口给予氮氧自由基自旋探针后，应用体内电子自旋共振成像（ESR成像）技术。为了获得自旋探针在活体动物体内的确切分布，在体内应用了三维ESR成像程序。成像图片显示，给予的自旋探针首先位于胃中，然后输送到动物的肝脏、肾脏和心脏。