Garamszegi C, Dennerstein L, Dudley E, Guthrie J R, Ryan M, Burger H
Department of Psychiatry, University of Melbourne, Carlton, Victoria, Australia.
J Psychosom Obstet Gynaecol. 1998 Sep;19(3):165-73. doi: 10.3109/01674829809025694.
This study aims to assess the relationship between self-rated and menstrually defined menopausal status, assesses criteria women use in perceiving their own menopausal status and compares symptom reporting and hormonal levels for self-rated and menstrually defined menopausal status. Women in the third year of the longitudinal phase of the Melbourne Women's Midlife Health Project (n = 332) were asked to assess their own menopausal status and the basis for this assessment. They were also specifically questioned on current menstrual cycle characteristics and levels of follicle-stimulating hormone (FSH), estradiol and inhibin were measured. For 67% of the women, the two definitions of menopausal status were in agreement. In women menstrually defined as premenopausal, self-rated menopausal status of peri- or postmenopausal appeared to be based on the occurrence of symptoms. In women menstrually defined as postmenopausal, persistence of hot flushes was taken to mean that 'the menopause was still in progress' despite absence of menses for more than 12 months. In women menstrually defined as perimenopausal yet who self-rated as premenopausal, FSH was lower (p < 0.01) and inhibin higher (p = 0.05) than women who self-rated as peri- or postmenopausal. Women's perceptions of the menopause are based on symptoms. Self-rated menopausal status appears to relate more closely to a women's endocrine status than definitions based on purely menstrual cycle characteristics.
本研究旨在评估自我评定的绝经状态与月经界定的绝经状态之间的关系，评估女性在感知自身绝经状态时所使用的标准，并比较自我评定的绝经状态和月经界定的绝经状态下的症状报告及激素水平。墨尔本女性中年健康项目纵向研究阶段第三年的女性（n = 332）被要求评估自己的绝经状态及评估依据。她们还被专门询问了当前月经周期特征，并测量了促卵泡激素（FSH）、雌二醇和抑制素水平。67%的女性，两种绝经状态的定义是一致的。月经界定为绝经前的女性，自我评定为围绝经期或绝经后的绝经状态似乎基于症状的出现。月经界定为绝经后的女性，潮热持续存在被认为意味着“绝经仍在进行中”，尽管已经停经超过12个月。月经界定为围绝经期但自我评定为绝经前的女性，其FSH水平较低（p < 0.01），抑制素水平较高（p = 0.05），而自我评定为围绝经期或绝经后的女性则相反。女性对绝经的认知基于症状。自我评定的绝经状态似乎比基于单纯月经周期特征的定义更紧密地与女性的内分泌状态相关。
