Efimenko V N, Evtushenko S K, Khodakovskiĭ A V
Lik Sprava. 1998 Aug(6):67-9.
A phenotyping was done in respect of HLA system in 14 children with documented multiple sclerosis (MS), 20 children with potential MS, and 42 their near relations. HLA-B12 antigen was recordable with high frequency (RR = 6.29; P < 0.025) while HLA-B18 with low one (P < 0.01) as compared to normal subjects both among patients in the general group and in those with proved MS. The latter showed a tendency toward increase in frequency HLA-B7. Children with significant MS where there was an association in the phenotype of HLA-B12 or HLA-B7 with HLA-A3 ran predominantly an aggravating course while their association with HLA-A2 resulted in a more benign course. The results obtained in respect of HLA antigens in MS in children differ from those of other authors on MS in adults.
对14名确诊为多发性硬化症（MS）的儿童、20名疑似MS的儿童及其42名近亲进行了HLA系统的表型分析。与正常受试者相比，在一般组患者和确诊为MS的患者中，HLA - B12抗原的检出频率较高（相对风险率RR = 6.29；P < 0.025），而HLA - B18的检出频率较低（P < 0.01）。后者显示出HLA - B7频率增加的趋势。在显著MS的儿童中，HLA - B12或HLA - B7表型与HLA - A3相关时，病程主要呈加重趋势，而与HLA - A2相关时，病程则较为良性。儿童MS中关于HLA抗原的研究结果与其他作者关于成人MS的研究结果不同。
