Bertrams J, Kuwert E
Z Immunitatsforsch Immunobiol. 1976 Nov;152(3):200-8.
HLA antigen segregation analysis was performed in 38 families with a total of 52 multiple sclerosis (MS) patients including 14 families with 2 affected sibs. HLA-A3 and especially B7 occurred more frequently in familial MS cases (propositi) (A3: 42.9%, B7: 64.3%) than in non-familial cases (A3: 35.8%, B7: 35.3%). As could be expected from the increased phenotype frequencies of A3 and B7, the haplotype A3-B7 showed a disturbed segregation among the MS patients but not among their healthy sibs. A second haplotype, A1-B8, was found more frequently than expected among the MS patients but also among their unaffected sibs. These data may suggest increased MS susceptibility associated with the haplotype A3-B7 and, conversely autoimmune or protective properties associated with A1-B8 in MS patients and their healthy sibs, respectively.
对38个家庭共52例多发性硬化症（MS）患者进行了HLA抗原分离分析，其中包括14个有2名患病同胞的家庭。HLA - A3，尤其是B7，在家族性MS病例（先证者）中出现的频率（A3：42.9%，B7：64.3%）高于非家族性病例（A3：35.8%，B7：35.3%）。正如从A3和B7增加的表型频率所预期的那样，单倍型A3 - B7在MS患者中表现出分离紊乱，但在他们的健康同胞中没有。发现第二种单倍型A1 - B8在MS患者中出现的频率高于预期，但在他们未受影响的同胞中也是如此。这些数据可能表明与单倍型A3 - B7相关的MS易感性增加，相反，分别与MS患者及其健康同胞中A1 - B8相关的自身免疫或保护特性。
